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The book's title comes from an intriguing historical hypothesis. In 1812 Napoleon led an army of six hundred thousand into Russia and by the retreat fewer than ten thousand remained. Some have speculated that the buttons on the soldiers' uniforms were made of tin, and that tin gradually becomes brittle and crumbles at low temperatures; as the buttons failed one by one, soldiers in the bitter cold could not even keep their clothes fastened. The authors admit frankly that this claim has not been proven, but it captures the book's main point: a tiny change in a molecule can bring enormous consequences. The book also opens with a simple chemistry primer, explaining how the different position of a group of atoms can make a molecule's properties completely different.
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